Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050389-03
Application #
2188200
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1993-12-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Nelson, Kimberly J; Perkins, Arden; Van Swearingen, Amanda E D et al. (2018) Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal 28:521-536
Bolduc, Jesalyn A; Nelson, Kimberly J; Haynes, Alexina C et al. (2018) Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. J Biol Chem 293:11901-11912
Keyes, Jeremiah D; Parsonage, Derek; Yammani, Rama D et al. (2017) Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med 112:534-543
Parsonage, Derek; Sheng, Fang; Hirata, Ken et al. (2016) X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol 194:180-90
Buchko, Garry W; Perkins, Arden; Parsonage, Derek et al. (2016) Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics. Biomol NMR Assign 10:57-61
Perkins, Arden; Parsonage, Derek; Nelson, Kimberly J et al. (2016) Peroxiredoxin Catalysis at Atomic Resolution. Structure 24:1668-1678
Poole, Leslie B; Nelson, Kimberly J (2016) Distribution and Features of the Six Classes of Peroxiredoxins. Mol Cells 39:53-9
Cunniff, Brian; Newick, Kheng; Nelson, Kimberly J et al. (2015) Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One 10:e0127310
Karplus, P Andrew (2015) A primer on peroxiredoxin biochemistry. Free Radic Biol Med 80:183-90
Perkins, Arden; Nelson, Kimberly J; Parsonage, Derek et al. (2015) Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci 40:435-45

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