Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051210-04
Application #
2842514
Study Section
Project Start
1998-04-01
Project End
1999-03-31
Budget Start
Budget End
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Burns, Laura T; Wente, Susan R (2012) Trafficking to uncharted territory of the nuclear envelope. Curr Opin Cell Biol 24:341-9
Le Trong, Isolde; Stenkamp, Ronald E; Ibarra, Catherine et al. (2002) 1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site. Proteins 48:618-27
Adman, E T; Le Trong, I; Stenkamp, R E et al. (2001) Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y. Proteins 42:192-200
Nieslanik, B S; Dietze, E C; Atkins, W M et al. (1999) The locally denatured state of glutathione S-transferase A1-1: transition state analysis of ligand-dependent formation of the C-terminal helix. Pac Symp Biocomput :554-65
Khojasteh-Bakht, S C; Nelson, S D; Atkins, W M (1999) Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones. Arch Biochem Biophys 370:59-65
Nieslanik, B S; Dabrowski, M J; Lyon, R P et al. (1999) Stopped-flow kinetic analysis of the ligand-induced coil-helix transition in glutathione S-transferase A1-1: evidence for a persistent denatured state. Biochemistry 38:6971-80
Dietze, E C; Grillo, M P; Kalhorn, T et al. (1998) Thiol ester hydrolysis catalyzed by glutathione S-transferase A1-1. Biochemistry 37:14948-57
Cook, D L; Atkins, W M (1997) Enhanced detoxication due to distributive catalysis and toxic thresholds: a kinetic analysis. Biochemistry 36:10801-6
Atkins, W M; Dietze, E C; Ibarra, C (1997) Pressure-dependent ionization of Tyr 9 in glutathione S-transferase A1-1: contribution of the C-terminal helix to a ""soft"" active site. Protein Sci 6:873-81
Dietze, E C; Ibarra, C; Dabrowski, M J et al. (1996) Rational modulation of the catalytic activity of A1-1 glutathione S-transferase: evidence for incorporation of an on-face (pi...HO-Ar) hydrogen bond at tyrosine-9. Biochemistry 35:11938-44

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