Nonsterol Regulation of the Mevalonate Pathway

Simoni, Robert D.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM051324-03
• Application #: 2189766
• Study Section: Physiological Chemistry Study Section (PC)
• Project Start: 1994-08-01
• Project End: 1998-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Stanford University
• Department: Biology
• Type: Schools of Arts and Sciences
• DUNS #: 800771545
• City: Stanford
• State: CA
• Country: United States
• Zip Code: 94305

Publications

Meigs, T E; Simoni, R D (1997) Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. Arch Biochem Biophys 345:1-9

Meigs, T E; Roseman, D S; Simoni, R D (1996) Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. J Biol Chem 271:7916-22

Meigs, T E; Sherwood, S W; Simoni, R D (1995) Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. Exp Cell Res 219:461-70