Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM051347-01A2
Application #
2189813
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Xiang, Tian-Xiang; Anderson, Bradley D (2006) Conformational structure, dynamics, and solvation energies of small alanine peptides in water and carbon tetrachloride. J Pharm Sci 95:1269-87
Mayer, Peter Terry; Xiang, Tian-Xiang; Niemi, Riku et al. (2003) A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions. Biochemistry 42:1624-36
Xiang, Tian-xiang; Anderson, Bradley D (2002) A computer simulation of functional group contributions to free energy in water and a DPPC lipid bilayer. Biophys J 82:2052-66
Mayer, Peter T; Anderson, Bradley D (2002) Transport across 1,9-decadiene precisely mimics the chemical selectivity of the barrier domain in egg lecithin bilayers. J Pharm Sci 91:640-6
Xiang, T; Anderson, B D (2000) Influence of a transmembrane protein on the permeability of small molecules across lipid membranes. J Membr Biol 173:187-201
Xiang, T X; Chen, J; Anderson, B D (2000) A quantitative model for the dependence of solute permeability on peptide and cholesterol content in biomembranes. J Membr Biol 177:137-48
Mayer, P T; Xiang, T X; Anderson, B D (2000) Independence of substituent contributions to the transport of small molecule permeants in lipid bilayers. AAPS PharmSci 2:E14
Xiang, T X; Anderson, B D (1998) Phase structures of binary lipid bilayers as revealed by permeability of small molecules. Biochim Biophys Acta 1370:64-76
Xiang, T X; Anderson, B D (1998) Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape. Biophys J 75:2658-71
Xiang, T X; Anderson, B D (1997) Permeability of acetic acid across gel and liquid-crystalline lipid bilayers conforms to free-surface-area theory. Biophys J 72:223-37