Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051633-03
Application #
2190303
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1994-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Tang, Fuxing; Ouyang, Hui; Yang, Jerry Z et al. (2004) Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers. J Pharm Sci 93:1185-94
Horie, Kazutoshi; Tang, Fuxing; Borchardt, Ronald T (2003) Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res 20:161-8
Tang, Fuxing; Horie, Kazutoshi; Borchardt, Ronald T (2002) Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res 19:765-72
Tang, Fuxing; Horie, Kazutoshi; Borchardt, Ronald T (2002) Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res 19:773-9
Gao, J; Winslow, S L; Vander Velde, D et al. (2001) Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa. J Pept Res 57:361-73
Gao, J; Murase, O; Schowen, R L et al. (2001) A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res 18:171-6
Gao, J; Sudoh, M; Aube, J et al. (2001) Transport characteristics of peptides and peptidomimetics: I. N-methylated peptides as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa. J Pept Res 57:316-29
Sudoh, M; Pauletti, G M; Yao, W et al. (1998) Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers. Pharm Res 15:719-25
Li, J; Tamura, K; Lee, C P et al. (1998) Structure-affinity relationships of Val-Val and Val-Val-Val stereoisomers with the apical oligopeptide transporter in human intestinal Caco-2 cells. J Drug Target 5:317-27
Artursson, P; Borchardt, R T (1997) Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm Res 14:1655-8

Showing the most recent 10 out of 16 publications