Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051923-02
Application #
2190715
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Sha, Zhe; Schnell, Helena M; Ruoff, Kerstin et al. (2018) Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation. J Cell Biol 217:1757-1776
Kim, Hyoung Tae; Goldberg, Alfred L (2018) UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells. Proc Natl Acad Sci U S A 115:E11642-E11650
VerPlank, Jordan J S; Lokireddy, Sudarsanareddy; Feltri, M Laura et al. (2018) Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia 66:379-395
Kim, Hyoung Tae; Goldberg, Alfred L (2017) The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis. J Biol Chem 292:9830-9839
Weyburne, Emily S; Wilkins, Owen M; Sha, Zhe et al. (2017) Inhibition of the Proteasome ?2 Site Sensitizes Triple-Negative Breast Cancer Cells to ?5 Inhibitors and Suppresses Nrf1 Activation. Cell Chem Biol 24:218-230
VerPlank, Jordan J S; Goldberg, Alfred L (2017) Regulating protein breakdown through proteasome phosphorylation. Biochem J 474:3355-3371
Edison, Natalia; Curtz, Yael; Paland, Nicole et al. (2017) Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis. Cell Rep 21:442-454
Volodin, Alexandra; Kosti, Idit; Goldberg, Alfred Lewis et al. (2017) Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A 114:E1375-E1384
Kuo, Chueh-Ling; Goldberg, Alfred Lewis (2017) Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c. Proc Natl Acad Sci U S A 114:E3404-E3413
Collins, Galen Andrew; Goldberg, Alfred L (2017) The Logic of the 26S Proteasome. Cell 169:792-806

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