The cells of living organisms are crammed with exquisite macromolecular machinery that carries out the functions of life. The need to understand the operation of these biomolecules on a molecular level grows ever more crucial as medicine develops the technology to tailor drug treatments to control the behavior of specific proteins. Crystallography and vibrational spectroscopy are two experimental approaches that provide information on protein structure and dynamics in sufficient detail to advance understanding of protein function on a molecular level. Traditionally, these are viewed as complementary techniques - each has its own characteristic strengths and weaknesses. The work proposed here aims to exploit the strengths of each, while avoiding some of the limitations, by making full use of polarized infrared (IR) absorbance measurements on protein crystals.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052002-09
Application #
6653845
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Wehrle, Janna P
Project Start
1995-09-01
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2005-08-31
Support Year
9
Fiscal Year
2003
Total Cost
$158,500
Indirect Cost
Name
Northeastern University
Department
Physics
Type
Schools of Arts and Sciences
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115