Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052067-02
Application #
2190950
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
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Nghiem, Paul; Park, Peter K; Kim Ys, Yong-son et al. (2002) ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J Biol Chem 277:4428-34
Clemons, Paul A; Gladstone, Brian G; Seth, Abhinav et al. (2002) Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. Chem Biol 9:49-61
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Nghiem, P; Park, P K; Kim , Y et al. (2001) ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A 98:9092-7
Clemons, P A (1999) Design and discovery of protein dimerizers. Curr Opin Chem Biol 3:112-5
Schmidt, D R; Schreiber, S L (1999) Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry 38:14711-7

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