Structure, Mechanism, and Inhibitor Design for Hgprt

Grubmeyer, Charles T.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM052125-02
• Application #: 2191041
• Study Section: Physical Biochemistry Study Section (PB)
• Project Start: 1995-08-04
• Project End: 1998-08-03
• Budget Start: 1996-08-04
• Budget End: 1997-08-03
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Temple University
• Department: Biochemistry
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19122

Publications

Deng, Hua; Callender, Robert; Schramm, Vern L et al. (2010) Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue. Biochemistry 49:2705-14

Shi, W; Munagala, N R; Wang, C C et al. (2000) Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). Biochemistry 39:6781-90

Balendiran, G K; Molina, J A; Xu, Y et al. (1999) Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Sci 8:1023-31

Xu, Y; Grubmeyer, C (1998) Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base. Biochemistry 37:4114-24

Sharma, V; Grubmeyer, C; Sacchettini, J C (1998) Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target. Structure 6:1587-99

Xu, Y; Eads, J; Sacchettini, J C et al. (1997) Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry. Biochemistry 36:3700-12