Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052212-08
Application #
6636117
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Cole, Alison E
Project Start
1994-08-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
8
Fiscal Year
2003
Total Cost
$295,000
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Brosnan, Heather; Bickler, Philip E (2013) Xenon neurotoxicity in rat hippocampal slice cultures is similar to isoflurane and sevoflurane. Anesthesiology 119:335-44
Warren, D E; Bickler, P E; Clark, J P et al. (2012) Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity. Neuroscience 207:316-25
Bickler, Philip E; Warren, Daniel E; Clark, John P et al. (2012) Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity. Anesthesiology 117:280-92
Bickler, Philip E; Fahlman, Christian S; Gray, Jonathan J (2010) Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation. J Neurosci Res 88:3520-9
Bickler, Philip E; Fahlman, Christian S (2010) Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res 1340:86-95
Stratmann, Greg; Sall, Jeffrey W; Bell, Joseph S et al. (2010) Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology 112:305-15
Rubinsky, Liel; Raichman, Nadav; Lavee, Jacob et al. (2010) Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Neurosci Res 67:256-9
Bickler, Philip E; Fahlman, Christian S (2009) Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures. Anesthesiology 111:258-66
Bickler, P E; Fahlman, C S; Gray, J et al. (2009) Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons. Neuroscience 160:51-60
Sall, Jeffrey W; Stratmann, Greg; Leong, Jason et al. (2009) Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology 110:826-33

Showing the most recent 10 out of 22 publications