Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052463-02
Application #
2191499
Study Section
Special Emphasis Panel (ZRG2-MGN (Q1))
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hansen, R S; Stoger, R; Wijmenga, C et al. (2000) Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant. Hum Mol Genet 9:2575-87
Handt, O; Baker, E; Dayan, S et al. (2000) Analysis of replication timing at the FRA10B and FRA16B fragile site loci. Chromosome Res 8:677-88
Wijmenga, C; Hansen, R S; Gimelli, G et al. (2000) Genetic variation in ICF syndrome: evidence for genetic heterogeneity. Hum Mutat 16:509-17
Hansen, R S; Wijmenga, C; Luo, P et al. (1999) The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A 96:14412-7
Gartler, S M; Goldstein, L; Tyler-Freer, S E et al. (1999) The timing of XIST replication: dominance of the domain. Hum Mol Genet 8:1085-9
Huber, R; Hansen, R S; Strazzullo, M et al. (1999) DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1. Proc Natl Acad Sci U S A 96:616-21
Hansen, R S; Canfield, T K; Stanek, A M et al. (1998) Reactivation of XIST in normal fibroblasts and a somatic cell hybrid: abnormal localization of XIST RNA in hybrid cells. Proc Natl Acad Sci U S A 95:5133-8