Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052543-02
Application #
2191611
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1995-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Haghjoo, Erik; Galan, Jorge E (2004) Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci U S A 101:4614-9
Hernandez, Lorraine D; Pypaert, Marc; Flavell, Richard A et al. (2003) A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol 163:1123-31
Kubori, Tomoko; Galan, Jorge E (2003) Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation. Cell 115:333-42
Carlyon, Jason A; Chan, Wai-Tsing; Galan, Jorge et al. (2002) Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. J Immunol 169:7009-18
Murli, S; Watson, R O; Galan, J E (2001) Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells. Cell Microbiol 3:795-810
Galan, J E (2001) Salmonella interactions with host cells: type III secretion at work. Annu Rev Cell Dev Biol 17:53-86
Zhou, D; Chen, L M; Hernandez, L et al. (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol Microbiol 39:248-59
Galan, J E; Zhou, D (2000) Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc Natl Acad Sci U S A 97:8754-61
Galan, J E; Fu, Y (2000) Modulation of actin cytoskeleton by Salmonella GTPase activating protein SptP. Methods Enzymol 325:496-504
Mitra, K; Zhou, D; Galan, J E (2000) Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica. FEBS Lett 482:81-4

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