Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM052682-01A1
Application #
2191795
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1996-03-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Iyanagi, Takashi; Xia, Chuanwu; Kim, Jung-Ja P (2012) NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. Arch Biochem Biophys 528:72-89
Xia, Chuanwu; Panda, Satya P; Marohnic, Christopher C et al. (2011) Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A 108:13486-91
Xia, Chuanwu; Hamdane, Djemel; Shen, Anna L et al. (2011) Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding. J Biol Chem 286:16246-60
Xia, Chuanwu; Misra, Ila; Iyanagi, Takashi et al. (2009) Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase. J Biol Chem 284:30708-17
Hamdane, Djemel; Xia, Chuanwu; Im, Sang-Choul et al. (2009) Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem 284:11374-84
Sarapusit, Songklod; Xia, Chuanwu; Misra, Ila et al. (2008) NADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stability. Arch Biochem Biophys 477:53-9
Jachymova, M; Martasek, P; Panda, S et al. (2005) Recruitment of governing elements for electron transfer in the nitric oxide synthase family. Proc Natl Acad Sci U S A 102:15833-8
Hubbard, P A; Shen, A L; Paschke, R et al. (2001) NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J Biol Chem 276:29163-70
Zhang, J; Martasek, P; Paschke, R et al. (2001) Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase. J Biol Chem 276:37506-13
Roman, L J; Miller, R T; de La Garza, M A et al. (2000) The C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain. J Biol Chem 275:21914-9

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