Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052738-03
Application #
2191878
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1994-09-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Hu, Hong-Yu; Horton, Julie K; Gryk, Michael R et al. (2004) Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. J Biol Chem 279:39736-44
Marintchev, Assen; Gryk, Michael R; Mullen, Gregory P (2003) Site-directed mutagenesis analysis of the structural interaction of the single-strand-break repair protein, X-ray cross-complementing group 1, with DNA polymerase beta. Nucleic Acids Res 31:580-8
Gryk, Michael R; Maciejewski, Mark W; Robertson, Anthony et al. (2002) 1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta. J Biomol NMR 22:197-8
Gryk, Michael R; Marintchev, Assen; Maciejewski, Mark W et al. (2002) Mapping of the interaction interface of DNA polymerase beta with XRCC1. Structure 10:1709-20
Pan, B; Maciejewski, M W; Marintchev, A et al. (2001) Solution structure of the catalytic domain of gammadelta resolvase. Implications for the mechanism of catalysis. J Mol Biol 310:1089-107
Maciejewski, M W; Pan, B; Shin, R et al. (2001) 1H, 15N, and 13C resonance assignments for a 20 kDa DNA polymerase from African swine fever virus. J Biomol NMR 21:177-8
Maciejewski, M W; Liu, D; Prasad, R et al. (2000) Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. J Mol Biol 296:229-53
Marintchev, A; Robertson, A; Dimitriadis, E K et al. (2000) Domain specific interaction in the XRCC1-DNA polymerase beta complex. Nucleic Acids Res 28:2049-59
Marintchev, A; Maciejewski, M W; Mullen, G P (1999) 1H, 15N, and 13C resonance assignments for the N-terminal 20 kDa domain of the DNA single-strand break repair protein XRCC1. J Biomol NMR 13:393-4
Mullen, G P; Wilson, S H (1997) DNA polymerase beta in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry 36:4713-7

Showing the most recent 10 out of 11 publications