Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052908-02
Application #
2192111
Study Section
Molecular Biology Study Section (MBY)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Ruan, Chun; Workman, Jerry L; Simpson, Robert T (2005) The DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type switching. Mol Cell Biol 25:8476-85
Wang, X; Simpson, R T (2001) Chromatin structure mapping in Saccharomyces cerevisiae in vivo with DNase I. Nucleic Acids Res 29:1943-50
Gavin, I M; Kladde, M P; Simpson, R T (2000) Tup1p represses Mcm1p transcriptional activation and chromatin remodeling of an a-cell-specific gene. EMBO J 19:5875-83
Kladde, M P; Xu, M; Simpson, R T (1999) DNA methyltransferases as probes for chromatin structure in yeast. Methods Mol Biol 119:395-416
Kladde, M P; Xu, M; Simpson, R T (1999) DNA methyltransferases as probes of chromatin structure in vivo. Methods Enzymol 304:431-47
Simpson, R T (1998) Chromatin structure and analysis of mechanisms of activators and repressors. Methods 15:283-94
Du, J; Nasir, I; Benton, B K et al. (1998) Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins. Genetics 150:987-1005
Kladde, M P; Simpson, R T (1998) Rapid detection of functional expression of C-5-DNA methyltransferases in yeast. Nucleic Acids Res 26:1354-5
Xu, M; Simpson, R T; Kladde, M P (1998) Gal4p-mediated chromatin remodeling depends on binding site position in nucleosomes but does not require DNA replication. Mol Cell Biol 18:1201-12
Xu, M; Kladde, M P; Van Etten, J L et al. (1998) Cloning, characterization and expression of the gene coding for a cytosine-5-DNA methyltransferase recognizing GpC. Nucleic Acids Res 26:3961-6

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