Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053049-01A1
Application #
2192301
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Pathology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Rudenko, Andrii; Dawlaty, Meelad M; Seo, Jinsoo et al. (2013) Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 79:1109-1122
Su, Susan C; Rudenko, Andrii; Cho, Sukhee et al. (2013) Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment. Neurobiol Learn Mem 105:54-62
Su, Susan C; Seo, Jinsoo; Pan, Jen Q et al. (2012) Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 75:675-87
Patzke, Holger; Maddineni, Upendra; Ayala, Ramses et al. (2003) Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci 23:2769-78
Patzke, Holger; Tsai, Li-Huei (2002) Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J Biol Chem 277:8054-60
Ko, J; Humbert, S; Bronson, R T et al. (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21:6758-71
Humbert, S; Lanier, L M; Tsai, L H (2000) Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport 11:2213-6
Humbert, S; Dhavan, R; Tsai, L (2000) p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci 113 ( Pt 6):975-83
Kwon, Y T; Tsai, L H; Crandall, J E (1999) Callosal axon guidance defects in p35(-/-) mice. J Comp Neurol 415:218-29
Kwon, Y T; Tsai, L H (1998) A novel disruption of cortical development in p35(-/-) mice distinct from reeler. J Comp Neurol 395:510-22

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