Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053114-01A1
Application #
2192394
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Grutkoski, P S; Graeber, C T; Lim, Y P et al. (2003) Alpha-defensin 1 (human neutrophil protein 1) as an antichemotactic agent for human polymorphonuclear leukocytes. Antimicrob Agents Chemother 47:2666-8
Grutkoski, Patricia S; Graeber, C Thomas; Ayala, Alfred et al. (2002) Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak. Shock 17:47-54
Grutkoski, Patricia S; D'Amico, Ron; Ayala, Alfred et al. (2002) Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner. Crit Care Med 30:591-7
Dunican, A; Grutkoski, P; Leuenroth, S et al. (2000) Neutrophils regulate their own apoptosis via preservation of CXC receptors. J Surg Res 90:32-8
Leuenroth, S J; Grutkoski, P S; Ayala, A et al. (2000) The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis. J Leukoc Biol 68:158-66
Leuenroth, S J; Grutkoski, P S; Ayala, A et al. (2000) Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity. Surgery 128:171-7
Dunican, A L; Leuenroth, S J; Ayala, A et al. (2000) CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent. Shock 13:244-50
Dunican, A L; Leuenroth, S J; Grutkoski, P et al. (2000) TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production. Shock 14:284-8; discussion 288-9
Grutkoski, P S; D'Amico, R; Ayala, A et al. (1999) IL-1beta stimulation induces paracrine regulation of PMN function and apoptosis. Shock 12:373-81
Grutkoski, P S; Graeber, C T; D'Amico, R et al. (1999) Regulation of IL-8RA (CXCR1) expression in polymorphonuclear leukocytes by hypoxia/reoxygenation. J Leukoc Biol 65:171-8

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