Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053536-01A1
Application #
2192910
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1996-09-30
Project End
2000-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Nash, Craig A; Brown, Loren M; Malik, Sundeep et al. (2018) Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase C? signaling in cardiac myocytes. J Mol Cell Cardiol 121:51-59
Madukwe, Jerry C; Garland-Kuntz, Elisabeth E; Lyon, Angeline M et al. (2018) G protein ?? subunits directly interact with and activate phospholipase C?. J Biol Chem 293:6387-6397
Kim, Kyun-Do; Bae, Seyeon; Capece, Tara et al. (2017) Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment. Nat Commun 8:15365
Tong, Jiaqing; Liu, Xiaojie; Vickstrom, Casey et al. (2017) The Epac-Phospholipase C? Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons. J Neurosci 37:3030-3044
Strazza, Marianne; Azoulay-Alfaguter, Inbar; Peled, Michael et al. (2017) PLC?1 regulates SDF-1?-induced lymphocyte adhesion and migration to sites of inflammation. Proc Natl Acad Sci U S A 114:2693-2698
DiStefano, Peter V; Smrcka, Alan V; Glading, Angela J (2016) Phospholipase C? Modulates Rap1 Activity and the Endothelial Barrier. PLoS One 11:e0162338
Bijli, Kaiser M; Fazal, Fabeha; Slavin, Spencer A et al. (2016) Phospholipase C-? signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury. Am J Physiol Lung Cell Mol Physiol 311:L517-24
Smrcka, Alan V (2015) Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes. J Cardiovasc Pharmacol 65:203-10
Dusaban, Stephanie S; Kunkel, Maya T; Smrcka, Alan V et al. (2015) Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem 290:26776-83
Kalwa, Hermann; Storch, Ursula; Demleitner, Jana et al. (2015) Phospholipase C epsilon (PLC?) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol 230:1389-99

Showing the most recent 10 out of 29 publications