The broad long-term objectives of this investigation are to implement a paradigm for the statistical analysis of marker rhythms of the human circadian system for subjects observed under the forced desynchrony protocol. The statistical models will be based on physiologically plausible descriptions of the interaction between the circadian system and the light-dark cycle. One developed, this analysis paradigm should offer a clearer quantitative description of fundamental circadian properties and the relation between the circadian system and the light- dark cycle studied under this protocol.
The specific aims of this project are to: 1) Develop biologically plausible statistical models of human plasma melatonin, plasma cortisol, and core temperature data collected under the forced desynchrony protocol; 2) Develop maximum likelihood and Bayesian statistical methods for fitting the models to experimental data; 3) Test the ability of the methods to quantify circadian and non-circadian properties on actual melatonin, cortisol and core-temperature data from young healthy subjects studied under the forced desynchrony protocol; 4) Apply the methods in actual data analysis problem being undertaken by circadian researchers. The experimental design and methods used are: (1) theoretical work to design statistical models; (2) empirical studies of human circadian data collected on the forced desynchrony protocol; and (3) computer simulations for the purpose of statistical model estimation and testing of statistical algorithms. The health-related implications of this investigation are a better quantitative understanding of the normal physiologic properties of the human biological clock which may be used to define more accurately disease states and develop therapies for disorders associated with the human circadian pacemaker.
|Vijayan, Sujith; Klerman, Elizabeth B; Adler, Gail K et al. (2015) Thalamic mechanisms underlying alpha-delta sleep with implications for fibromyalgia. J Neurophysiol 114:1923-30|
|Faghih, Rose T; Dahleh, Munther A; Adler, Gail K et al. (2015) Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng 62:2379-88|
|Faghih, Rose T; Dahleh, Munther A; Adler, Gail K et al. (2014) Deconvolution of serum cortisol levels by using compressed sensing. PLoS One 9:e85204|
|Indic, Premananda; Forger, Daniel B; St Hilaire, Melissa A et al. (2005) Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int 22:613-29|
|Brown, Emery N; Solo, Victor; Choe, Yong et al. (2004) Measuring period of human biological clock: infill asymptotic analysis of harmonic regression parameter estimates. Methods Enzymol 383:382-405|
|Klerman, Elizabeth B; Adler, Gail K; Jin, Moonsoo et al. (2003) A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab 285:E1118-26|
|Brown, E N; Meehan, P M; Dempster, A P (2001) A stochastic differential equation model of diurnal cortisol patterns. Am J Physiol Endocrinol Metab 280:E450-61|
|Brown, E N; Choe, Y; Luithardt, H et al. (2000) A statistical model of the human core-temperature circadian rhythm. Am J Physiol Endocrinol Metab 279:E669-83|
|Brown, E N; Luithardt, H (1999) Statistical model building and model criticism for human circadian data. J Biol Rhythms 14:609-16|
|Czeisler, C A; Brown, E N (1999) Commentary: models of the effect of light on the human circadian system: current state of the art. J Biol Rhythms 14:538-43|
Showing the most recent 10 out of 12 publications