Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053645-01
Application #
2193030
Study Section
Biochemistry Study Section (BIO)
Project Start
1996-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Steegborn, Clemens; Litvin, Tatiana N; Hess, Kenneth C et al. (2005) A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem 280:31754-9
Clapp, Peter; Capper, Austin B; Taussig, Ronald (2002) Genetic selection of regulatory mutants of mammalian adenylyl cyclases. Methods Enzymol 345:241-51
Scott, J K; Huang, S F; Gangadhar, B P et al. (2001) Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. EMBO J 20:767-76
Watts, V J; Taussig, R; Neve, R L et al. (2001) Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Galphas: characterization of Galphas-insensitive mutants of adenylyl cyclase V. Mol Pharmacol 60:1168-72
Hou, Y; Chang, V; Capper, A B et al. (2001) G Protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3. J Biol Chem 276:19982-8
Shoshani, I; Taussig, R; Iyengar, R et al. (2000) Synthesis and use of 3'-(azidoiodosalicyl) derivatives of 2', 5'-dideoxyadenosine as photoaffinity ligands for adenylyl cyclase. Arch Biochem Biophys 376:221-8
Zimmermann, G; Zhou, D; Taussig, R (1999) Activating mutation of adenylyl cyclase reverses its inhibition by G proteins. Mol Pharmacol 56:895-901
Lan, K L; Sarvazyan, N A; Taussig, R et al. (1998) A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins. J Biol Chem 273:12794-7
Taussig, R; Zimmermann, G (1998) Type-specific regulation of mammalian adenylyl cyclases by G protein pathways. Adv Second Messenger Phosphoprotein Res 32:81-98
Zimmermann, G; Zhou, D; Taussig, R (1998) Genetic selection of mammalian adenylyl cyclases insensitive to stimulation by Gsalpha. J Biol Chem 273:6968-75

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