Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054516-02
Application #
2193873
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-09-30
Project End
1997-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Fritz, F; Howard, E M; Hoffman, M M et al. (1999) Evidence for altered ion transport in Saccharomyces cerevisiae overexpressing human MDR 1 protein. Biochemistry 38:4214-26
Weisburg, J H; Roepe, P D; Dzekunov, S et al. (1999) Intracellular pH and multidrug resistance regulate complement-mediated cytotoxicity of nucleated human cells. J Biol Chem 274:10877-88
Santai, C T; Fritz, F; Roepe, P D (1999) Effects of ion gradients on H+ transport mediated by human MDR 1 protein. Biochemistry 38:4227-34
Roepe, P D; Martiney, J A (1999) Are ion-exchange processes central to understanding drug-resistance phenomena? Trends Pharmacol Sci 20:62-5
Robinson, L J; Roberts, W K; Ling, T T et al. (1997) Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry 36:11169-78
Wei, L Y; Hoffman, M M; Roepe, P D (1997) Altered pHi regulation in 3T3/CFTR clones and their chemotherapeutic drug-selected derivatives. Am J Physiol 272:C1642-53
Wadkins, R M; Roepe, P D (1997) Biophysical aspects of P-glycoprotein-mediated multidrug resistance. Int Rev Cytol 171:121-65
Hoffman, M M; Roepe, P D (1997) Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression. Biochemistry 36:11153-68
Hoffman, M M; Wei, L Y; Roepe, P D (1996) Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance? J Gen Physiol 108:295-313
Roepe, P D; Wei, L Y; Hoffman, M M et al. (1996) Altered drug translocation mediated by the MDR protein: direct, indirect, or both? J Bioenerg Biomembr 28:541-55

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