Abstract

The general aim of this project is to determine the molecular and quantitative genetic basis of mating behavior in Drosophila.
The specific aims are to map with high resolution the quantitative trait loci (QTL) responsible for intra-specific variation in courtship initiation time and time to copulation in Drosophila melanogaster; and to map QTL associated with pre-zygotic reproductive isolation between D. mauritiana and D. simulans. Previously, I mapped QTL responsible for variation in male mating behavior between two D. melanogaster strains. Deficiency and recombination mapping will be used to map these QTL with high resolution, and complementation testing will be used to identify candidate genes responsible for naturally occurring variation in behavior. The number, map positions and effects of QTL responsible for ethological divergence between species will be determined by associating mating behavior with polymorphic molecular markers in interspecific backcross hybrids.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM055321-09
Application #
6830706
Study Section
Genetics Study Section (GEN)
Program Officer
Anderson, Richard A
Project Start
1997-01-01
Project End
2006-12-31
Budget Start
2005-01-01
Budget End
2006-12-31
Support Year
9
Fiscal Year
2005
Total Cost
$125,291
Indirect Cost

  Institution

Name
University of California Riverside
Department
Other Basic Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
627797426
City
Riverside
State
CA
Country
United States
Zip Code
92521

  Publications

Jia, Zhenyu; Tang, Sha; Mercola, Dan et al. (2008) Detection of Quantitative Trait Associated Genes Using Cluster Analysis. Lect Notes Comput Sci 4973:83-94
Yang, Runqing; Li, Jiahan; Xu, Shizhong (2008) Mapping quantitative trait loci for traits defined as ratios. Genetica 132:323-9
Xu, Shizhong; Jia, Zhenyu (2007) Genomewide analysis of epistatic effects for quantitative traits in barley. Genetics 175:1955-63
Jia, Zhenyu; Xu, Shizhong (2007) Mapping quantitative trait loci for expression abundance. Genetics 176:611-23
Yang, Runqing; Xu, Shizhong (2007) Bayesian shrinkage analysis of quantitative trait Loci for dynamic traits. Genetics 176:1169-85
Xu, Shizhong (2007) An empirical Bayes method for estimating epistatic effects of quantitative trait loci. Biometrics 63:513-21
Xu, S; Xu, C (2006) A multivariate model for ordinal trait analysis. Heredity 97:409-17
Yang, Runqing; Yi, Nengjun; Xu, Shizhong (2006) Box-Cox transformation for QTL mapping. Genetica 128:133-43
Yang, Runqing; Tian, Quan; Xu, Shizhong (2006) Mapping quantitative trait loci for longitudinal traits in line crosses. Genetics 173:2339-56
Qu, Yi; Xu, Shizhong (2006) Quantitative trait associated microarray gene expression data analysis. Mol Biol Evol 23:1558-73

Showing the most recent 10 out of 53 publications