Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM055695-02S1
Application #
6042719
Study Section
Medical Biochemistry Study Section (MEDB)
Program Officer
Marino, Pamela
Project Start
1998-02-01
Project End
2002-01-31
Budget Start
1999-12-01
Budget End
2000-01-31
Support Year
2
Fiscal Year
2000
Total Cost
$25,288
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Sharma, Vandana; Freeze, Hudson H (2011) Mannose efflux from the cells: a potential source of mannose in blood. J Biol Chem 286:10193-200
Freeze, Hudson H (2009) Towards a therapy for phosphomannomutase 2 deficiency, the defect in CDG-Ia patients. Biochim Biophys Acta 1792:835-40
DeRossi, Charles; Bode, Lars; Eklund, Erik A et al. (2006) Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem 281:5916-27
Wu, Xiaohua; Freeze, Hudson H (2002) GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. Genomics 80:553-7
Wu, Xiaohua; Li, Weizhong; Sharma, Vandana et al. (2002) Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol Genet Metab 76:37-45
Davis, Joseph A; Wu, Xiao-Hua; Wang, Ling et al. (2002) Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase. Glycobiology 12:435-42
Davis, J A; Freeze, H H (2001) Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Biochim Biophys Acta 1528:116-26
Freeze, H H; Westphal, V (2001) Balancing N-linked glycosylation to avoid disease. Biochimie 83:791-9
Freeze, H H (2001) Update and perspectives on congenital disorders of glycosylation. Glycobiology 11:129R-143R
Kim, S; Westphal, V; Srikrishna, G et al. (2000) Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie) J Clin Invest 105:191-8

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