Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM055979-01
Application #
2194320
Study Section
Molecular Biology Study Section (MBY)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Cevallos, Randal C; Sarnow, Peter (2005) Factor-independent assembly of elongation-competent ribosomes by an internal ribosome entry site located in an RNA virus that infects penaeid shrimp. J Virol 79:677-83
Cherry, Sara; Doukas, Tammy; Armknecht, Susan et al. (2005) Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev 19:445-52
Qin, Xiaoli; Sarnow, Peter (2004) Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells. J Biol Chem 279:13721-8
Spahn, Christian M T; Jan, Eric; Mulder, Anke et al. (2004) Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell 118:465-75
Jan, Eric; Kinzy, Terri Goss; Sarnow, Peter (2003) Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis. Proc Natl Acad Sci U S A 100:15410-5
Sarnow, Peter (2003) Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J Virol 77:2801-6
Thompson, Sunnie R; Sarnow, Peter (2003) Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology 315:259-66
Bushell, Martin; Sarnow, Peter (2002) Hijacking the translation apparatus by RNA viruses. J Cell Biol 158:395-9
Fernandez, James; Yaman, Ibrahim; Sarnow, Peter et al. (2002) Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha. J Biol Chem 277:19198-205
Jan, Eric; Sarnow, Peter (2002) Factorless ribosome assembly on the internal ribosome entry site of cricket paralysis virus. J Mol Biol 324:889-902

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