Abstract

(from Abstract) Mutations in the eyelid gene, eld, cause phenotypes opposite to those of wg mutations in the Drosophila eye, wing, and embryo, suggesting that one of the functions of eld is to antagonize wg activity. Eld encodes a proline rich nuclear protein with homology to a family of novel DNA binding domains. The PI proposes to determine the function of the eld protein using biochemical and genetic methods.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056131-04
Application #
6386710
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Greenberg, Judith H
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$243,109
Indirect Cost

  Institution

Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Marr, Sharon K; Lis, John T; Treisman, Jessica E et al. (2014) The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster. Mol Cell Biol 34:2710-20
Janody, Florence; Treisman, Jessica E (2011) Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev Dyn 240:2051-9
Li, Xuan Shirley; Trojer, Patrick; Matsumura, Tatsushi et al. (2010) Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. Mol Cell Biol 30:1673-88
Carrera, Ines; Treisman, Jessica E (2008) Message in a nucleus: signaling to the transcriptional machinery. Curr Opin Genet Dev 18:397-403