This proposed research focuses on the development of models and statistical methods for analyzing event observations. The observations are obtained by following subjects undergoing intervention programs designed to prolong the time to the next occurrence of the recurrent event of interest (e.g., a return to substance abuse, another heart attack, another period of depression, to name a few). We will develop methods for predicting the time to the next occurrence, for comparing various types of interventions (e.g. competing treatments) and determining the relative efficacies, and for assessing which factors (covariates) significantly affect the time to the next event. Our models and methods are richer and more flexible than standard approaches, including Cox's proportional hazards model based on time-dependent covariates. In particular, our models simultaneously incorporate intervention effects, weakening (or strengthening) effects of the number of event occurrences, and the effects of the covariates. We will use the methods to analyze various data sets including hospitalization data from the US Renal Data System.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM056182-01A1
Application #
2677469
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Starks, Vaurice
Project Start
1998-07-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Bowling Green State University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
617407325
City
Bowling Green
State
OH
Country
United States
Zip Code
43403
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