Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056492-02
Application #
6181066
Study Section
Special Emphasis Panel (ZRG1-IMS (01))
Program Officer
Tompkins, Laurie
Project Start
1999-08-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
2
Fiscal Year
2000
Total Cost
$331,958
Indirect Cost

  Institution

Name
Immune Disease Institute, Inc.
Department
Type
DUNS #
115524410
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Falvo, James V; Lin, Charles H; Tsytsykova, Alla V et al. (2008) A dimer-specific function of the transcription factor NFATp. Proc Natl Acad Sci U S A 105:19637-42
Ranjbar, Shahin; Rajsbaum, Ricardo; Goldfeld, Anne E (2006) Transactivator of transcription from HIV type 1 subtype E selectively inhibits TNF gene expression via interference with chromatin remodeling of the TNF locus. J Immunol 176:4182-90
Esensten, Jonathan H; Tsytsykova, Alla V; Lopez-Rodriguez, Cristina et al. (2005) NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone. Nucleic Acids Res 33:3845-54
Barthel, Robert; Tsytsykova, Alla V; Barczak, Amy K et al. (2003) Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300. Mol Cell Biol 23:526-33
Barthel, Robert; Goldfeld, Anne E (2003) T cell-specific expression of the human TNF-alpha gene involves a functional and highly conserved chromatin signature in intron 3. J Immunol 171:3612-9
Baena, A; Leung, J Y; Sullivan, A D et al. (2002) TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestry. Genes Immun 3:482-7
Tsytsykova, Alla V; Goldfeld, Anne E (2002) Inducer-specific enhanceosome formation controls tumor necrosis factor alpha gene expression in T lymphocytes. Mol Cell Biol 22:2620-31
Falvo, J V; Brinkman, B M; Tsytsykova, A V et al. (2000) A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. Proc Natl Acad Sci U S A 97:3925-9
Tsai, E Y; Falvo, J V; Tsytsykova, A V et al. (2000) A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol 20:6084-94
Goldfeld, A E; Leung, J Y; Sawyer, S A et al. (2000) Post-genomics and the neutral theory: variation and conservation in the tumor necrosis factor-alpha promoter. Gene 261:19-25

Showing the most recent 10 out of 12 publications