Abstract

Dr. Blumberg has identified a novel Dictyostelium protein that has anti-adhesion motifs, and preliminary findings indicate that it plays a role in regulating adhesion, cell migration, and tissue development. A thorough, well thought-out, and focused set of experiments is proposed to learn more about how this protein regulates cell adhesion and migration behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056690-04
Application #
6342957
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Flicker, Paula F
Project Start
1998-01-01
Project End
2003-12-31
Budget Start
2001-01-01
Budget End
2003-12-31
Support Year
4
Fiscal Year
2001
Total Cost
$191,545
Indirect Cost

  Institution

Name
University of Maryland Balt CO Campus
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21250

  Publications

Cost, Hoa N; Noratel, Elizabeth F; Blumberg, Daphne D (2013) AmpA protein functions by different mechanisms to influence early cell type specification and to modulate cell adhesion and actin polymerization in Dictyostelium discoideum. Differentiation 86:1-12
Noratel, Elizabeth F; Petty, Chere' L; Kelsey, Jessica S et al. (2012) The adhesion modulation protein, AmpA localizes to an endocytic compartment and influences substrate adhesion, actin polymerization and endocytosis in vegetative Dictyostelium cells. BMC Cell Biol 13:29
Peletskaya, Elena N; Kogon, Alex A; Tuske, Steven et al. (2004) Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA. J Virol 78:3387-97
Blumberg, Daphne D; Ho, Hoa N; Petty, Chere' L et al. (2002) AmpA, a modular protein containing disintegrin and ornatin domains, has multiple effects on cell adhesion and cell fate specification. J Muscle Res Cell Motil 23:817-28
Varney, Timothy R; Casademunt, Elisabeth; Ho, Hoa N et al. (2002) A novel Dictyostelium gene encoding multiple repeats of adhesion inhibitor-like domains has effects on cell-cell and cell-substrate adhesion. Dev Biol 243:226-48
Sarafianos, Stefan G; Clark Jr, Arthur D; Das, Kalyan et al. (2002) Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. EMBO J 21:6614-24
Varney, Timothy R; Ho, Hoa; Petty, Chere' et al. (2002) A novel disintegrin domain protein affects early cell type specification and pattern formation in Dictyostelium. Development 129:2381-9
Casademunt, Elisabeth; Varney, Timothy R; Dolman, Jayne et al. (2002) A gene encoding a novel anti-adhesive protein is expressed in growing cells and restricted to anterior-like cells during development of Dictyostelium. Differentiation 70:23-35