Abstract

The principal investigator proposes to utilize Drosophila melanogaster in his studies of the components of the olfactory signal transduction pathways. Mutants generated by P-element insertion will be isolated and examined for phenotype, the sequence of the gene affected, reversion by P-element mutagenesis, tissue specificity of expression. The isolated gene will be expressed in the baculovirus system and if the gene resembles a receptor, the odorant-induced, second messengers will be examined in the Sf9 cells that are used to express the gene in baculovirus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM059469-06
Application #
6386500
Study Section
Special Emphasis Panel (ZRG1-MGN (02))
Program Officer
Hagan, Ann A
Project Start
1995-01-01
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
6
Fiscal Year
2001
Total Cost
$289,086
Indirect Cost

  Institution

Name
North Carolina State University Raleigh
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695

  Publications

Fochler, S; Morozova, T V; Davis, M R et al. (2017) Genetics of alcohol consumption in Drosophila melanogaster. Genes Brain Behav 16:675-685
Garcia, Júlia Frankenberg; Carbone, Mary Anna; Mackay, Trudy F C et al. (2017) Regulation of Drosophila Lifespan by bellwether Promoter Alleles. Sci Rep 7:4109
He, X; Zhou, S; St Armour, G E et al. (2016) Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. Genes Brain Behav 15:280-90
Shorter, John R; Dembeck, Lauren M; Everett, Logan J et al. (2016) Obp56h Modulates Mating Behavior in Drosophila melanogaster. G3 (Bethesda) 6:3335-3342
Arya, Gunjan H; Magwire, Michael M; Huang, Wen et al. (2015) The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Chem Senses 40:233-43
Dembeck, Lauren M; Böröczky, Katalin; Huang, Wen et al. (2015) Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Elife 4:
Anholt, Robert R H; Mackay, Trudy F C (2015) Dissecting the Genetic Architecture of Behavior in Drosophila melanogaster. Curr Opin Behav Sci 2:1-7
Huang, Wen; Carbone, Mary Anna; Magwire, Michael M et al. (2015) Genetic basis of transcriptome diversity in Drosophila melanogaster. Proc Natl Acad Sci U S A 112:E6010-9
Huang, Wen; Massouras, Andreas; Inoue, Yutaka et al. (2014) Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. Genome Res 24:1193-208
Zhou, Shanshan; Mackay, Trudy F C; Anholt, Robert R H (2014) Transcriptional and epigenetic responses to mating and aging in Drosophila melanogaster. BMC Genomics 15:927

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