Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM059986-01A1
Application #
6132620
Study Section
Special Emphasis Panel (ZRG1-MDCN-3 (01))
Program Officer
Shapiro, Bert I
Project Start
2000-04-01
Project End
2003-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
1
Fiscal Year
2000
Total Cost
$251,007
Indirect Cost
Name
University of Arizona
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Kourghi, Mohamad; Pei, Jinxin V; De Ieso, Michael L et al. (2016) Bumetanide Derivatives AqB007 and AqB011 Selectively Block the Aquaporin-1 Ion Channel Conductance and Slow Cancer Cell Migration. Mol Pharmacol 89:133-40
Baetz, Nicholas W; Stamer, W Daniel; Yool, Andrea J (2012) Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci 53:2127-32
Yool, Andrea J; Campbell, Ewan M (2012) Structure, function and translational relevance of aquaporin dual water and ion channels. Mol Aspects Med 33:553-61
Migliati, Elton; Meurice, Nathalie; DuBois, Pascale et al. (2009) Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Mol Pharmacol 76:105-12
Baetz, N W; Hoffman, E A; Yool, A J et al. (2009) Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. Exp Eye Res 89:95-100
Stamer, W Daniel; Chan, Darren W H; Conley, Shannon M et al. (2008) Aquaporin-1 expression and conventional aqueous outflow in human eyes. Exp Eye Res 87:349-55
Yool, Andrea J (2007) Functional domains of aquaporin-1: keys to physiology, and targets for drug discovery. Curr Pharm Des 13:3212-21
Yool, Andrea J (2007) Aquaporins: multiple roles in the central nervous system. Neuroscientist 13:470-85
Yool, Andrea J (2007) Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Gene Expr 13:329-37
Yu, Jin; Yool, Andrea J; Schulten, Klaus et al. (2006) Mechanism of gating and ion conductivity of a possible tetrameric pore in aquaporin-1. Structure 14:1411-23

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