The long term objective of this research is to determine the mechanisms by which the invertebrate nuclear receptor, ultraspiracle, transduces the regulatory signals of its endogenous ligands(s) into pathways for transcriptional activation. The proposed research builds upon their recent studies that have demonstrated that two natural dipteran epoxymethylfarnesoates bind with specificity to ultraspiracle so as to cause conformational change in that receptor, while closely related farnesoid pathway metabolites do not have this interaction with USP.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM060121-03
Application #
6387028
Study Section
Special Emphasis Panel (ZRG1-TMP (01))
Program Officer
Anderson, James J
Project Start
1999-05-01
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
3
Fiscal Year
2001
Total Cost
$256,530
Indirect Cost
Name
University of Kentucky
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Wozniak, Mietek; Chu, Yanxia; Fang, Fang et al. (2004) Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle. Insect Biochem Mol Biol 34:1147-62
Jones, G; Jones, D; Zhou, L et al. (2000) Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem 275:22157-65