Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM062120-05
Application #
6387282
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Schwab, John M
Project Start
2000-09-01
Project End
2004-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
5
Fiscal Year
2001
Total Cost
$375,749
Indirect Cost
Name
Yale University
Department
Physiology
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kim, Kyung Bo; Crews, Craig M (2013) From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Nat Prod Rep 30:600-4
Tae, Hyun Seop; Hines, John; Schneekloth, Ashley R et al. (2011) Unexpected stereochemical tolerance for the biological activity of tyroscherin. Bioorg Med Chem 19:1708-13
Tae, Hyun Seop; Hines, John; Schneekloth, Ashley R et al. (2010) Total synthesis and biological evaluation of tyroscherin. Org Lett 12:4308-11
Custar, Daniel W; Zabawa, Thomas P; Hines, John et al. (2009) Total synthesis and structure-activity investigation of the marine natural product neopeltolide. J Am Chem Soc 131:12406-14
Kim, Kyung Bo; Crews, Craig M (2008) Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors. J Med Chem 51:2600-5
Hines, John; Groll, Michael; Fahnestock, Margaret et al. (2008) Proteasome inhibition by fellutamide B induces nerve growth factor synthesis. Chem Biol 15:501-12
Corson, Timothy W; Crews, Craig M (2007) Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130:769-74
Petri, Andreas F; Schneekloth Jr, John S; Mandal, Amit K et al. (2007) Synthesis of the C3-C18 fragment of amphidinolides G and H. Org Lett 9:3001-4
Hines, John; Roy, Myriam; Cheng, Hua et al. (2006) Myriaporone 3/4 structure--activity relationship studies define a pharmacophore targeting eukaryotic protein synthesis. Mol Biosyst 2:371-9
Schneekloth Jr, John S; Sanders, John L; Hines, John et al. (2006) Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog. Bioorg Med Chem Lett 16:3855-8

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