The PI proposes to expand on previously published work of hers and develop a comprehensive semiparametric methodology for gene localization by linkage disequilibrium. The methods will be applicable to a variety of study designs and study populations. The proposed methods require only minimal assumptions about the population and the genetics of the disease and are computationally simple. Tools will be developed for validating the underlying assumptions of the model, for improving the gene location estimate and confidence interval given the model, and for providing guidelines as to the requirements and limitations of the methods in realistic genetics settings.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM062628-02
Application #
6387298
Study Section
Genome Study Section (GNM)
Program Officer
Eckstrand, Irene A
Project Start
2000-09-11
Project End
2005-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$211,950
Indirect Cost
Name
Stanford University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Noble, Janelle A; White, Amy M; Lazzeroni, Laura C et al. (2003) A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes 52:1579-82
Lazzeroni, Laura C (2002) Allele sharing and allelic association I: sib pair tests with increased power. Genet Epidemiol 22:328-44
Mirel, Daniel B; Valdes, Ana Maria; Lazzeroni, Laura C et al. (2002) Association of IL4R haplotypes with type 1 diabetes. Diabetes 51:3336-41
Lazzeroni, L C (2001) A chronology of fine-scale gene mapping by linkage disequilibrium. Stat Methods Med Res 10:57-76