Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM063471-06
Application #
6520543
Study Section
Pathobiochemistry Study Section (PBC)
Program Officer
Greenberg, Judith H
Project Start
1996-04-01
Project End
2005-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
6
Fiscal Year
2002
Total Cost
$291,000
Indirect Cost
Name
University of Wisconsin Madison
Department
Pathology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hopkins, Delana R; Keles, Sunduz; Greenspan, Daniel S (2007) The bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol 26:508-23
Ge, Gaoxiang; Greenspan, Daniel S (2006) Developmental roles of the BMP1/TLD metalloproteinases. Birth Defects Res C Embryo Today 78:47-68
Steiglitz, Barry M; Kreider, Jaclynn M; Frankenburg, Elizabeth P et al. (2006) Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues. Mol Cell Biol 26:238-49
Wang, Wei-Man; Ge, Gaoxiang; Lim, N H et al. (2006) TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2. Biochem J 398:515-9
Ge, Gaoxiang; Hopkins, Delana R; Ho, Wen-Bin et al. (2005) GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. Mol Cell Biol 25:5846-58
Gonzalez, Eva M; Reed, Charles C; Bix, Gregory et al. (2005) BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem 280:7080-7
Steiglitz, Barry M; Ayala, Melvin; Narayanan, Karthikeyan et al. (2004) Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem 279:980-6
Gopalakrishnan, Bagavathi; Wang, Wei-Man; Greenspan, Daniel S (2004) Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer. J Biol Chem 279:30904-12
Jasuja, Reema; Allen, Benjamin L; Pappano, William N et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J Biol Chem 279:51289-97
Ge, Gaoxiang; Seo, Neung-Seon; Liang, Xiaowen et al. (2004) Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. J Biol Chem 279:41626-33

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