This grant application describes a research program directed at the development of new synthetic technologies for organic synthesis and molecular diversity construction. Specifically, the proposed research aims to explore the synthetic potential of the DMP and IBX reagents and to develop synthetic technologies based on the photo-induced chemistry of o- substituted benzaldehydes and the reactivity of alpha-sulfonated carbonyl compounds, both in solution and on solid phase. Applications of the developed technologies to total synthesis and combinatorial chemistry are also proposed. The designed and synthesized compounds will be screened against a variety of biological assays for lead identification as a means to facilitate chemical biology studies and drug discovery programs in oncology and other disease areas.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM063752-01A1
Application #
6477946
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
2002-03-01
Project End
2006-02-28
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
1
Fiscal Year
2002
Total Cost
$351,705
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Nicolaou, K C; Ortiz, Adrian; Zhang, Hongjun et al. (2010) Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B. J Am Chem Soc 132:7153-76
Nicolaou, K C; Ortiz, Adrian; Zhang, Hongjun et al. (2010) Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B. J Am Chem Soc 132:7138-52
Nicolaou, K C; Zhang, Hongjun; Ortiz, Adrian et al. (2008) Total synthesis of the originally assigned structure of vannusal B. Angew Chem Int Ed Engl 47:8605-10