Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM064563-01S1
Application #
6696658
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Lewis, Catherine D
Project Start
2002-03-01
Project End
2007-02-28
Budget Start
2002-12-01
Budget End
2003-02-28
Support Year
1
Fiscal Year
2003
Total Cost
$16,395
Indirect Cost
Name
Ohio State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071650709
City
Columbus
State
OH
Country
United States
Zip Code
43210
de la Harpe, Kimberly; Crespo-Hernández, Carlos E; Kohler, Bern (2009) The excited-state lifetimes in a G x C DNA duplex are nearly independent of helix conformation and base-pairing motif. Chemphyschem 10:1421-5
de La Harpe, Kimberly; Crespo-Hernandez, Carlos E; Kohler, Bern (2009) Deuterium isotope effect on excited-state dynamics in an alternating GC oligonucleotide. J Am Chem Soc 131:17557-9
Hare, Patrick M; Middleton, Chris T; Mertel, Kristin I et al. (2008) Time-resolved infrared spectroscopy of the lowest triplet state of thymine and thymidine. Chem Phys 347:383-392
Takaya, Tomohisa; Su, Charlene; de La Harpe, Kimberly et al. (2008) UV excitation of single DNA and RNA strands produces high yields of exciplex states between two stacked bases. Proc Natl Acad Sci U S A 105:10285-90
Cohen, Boiko; Larson, Matthew H; Kohler, Bern (2008) Ultrafast excited-state dynamics of RNA and DNA C tracts. Chem Phys 350:165-174
Crespo-Hernandez, Carlos E; de la Harpe, Kimberly; Kohler, Bern (2008) Ground-state recovery following UV excitation is much slower in G x C-DNA duplexes and hairpins than in mononucleotides. J Am Chem Soc 130:10844-5
Law, Yu Kay; Azadi, Javad; Crespo-Hernandez, Carlos E et al. (2008) Predicting thymine dimerization yields from molecular dynamics simulations. Biophys J 94:3590-600
Schreier, Wolfgang J; Schrader, Tobias E; Koller, Florian O et al. (2007) Thymine dimerization in DNA is an ultrafast photoreaction. Science 315:625-9
Middleton, Chris T; Cohen, Boiko; Kohler, Bern (2007) Solvent and solvent isotope effects on the vibrational cooling dynamics of a DNA base derivative. J Phys Chem A 111:10460-7
Hare, Patrick M; Crespo-Hernandez, Carlos E; Kohler, Bern (2007) Internal conversion to the electronic ground state occurs via two distinct pathways for pyrimidine bases in aqueous solution. Proc Natl Acad Sci U S A 104:435-40

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