Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM065057-02
Application #
6693386
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (01))
Program Officer
Eckstrand, Irene A
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$338,800
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Zhang, Guoqing; Cai, Fangping; de Rivera, Ivette Lorenzana et al. (2016) Simultaneous Detection of Major Drug Resistance Mutations of HIV-1 Subtype B Viruses from Dried Blood Spot Specimens by Multiplex Allele-Specific Assay. J Clin Microbiol 54:220-2
Liu, Jia; Song, Hongshuo; Liu, Donglai et al. (2014) Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR. PLoS One 9:e106658
Zhang, Guoqing; Cai, Fangping; Zhou, Zhiyong et al. (2013) Simultaneous detection of major drug resistance mutations in the protease and reverse transcriptase genes for HIV-1 subtype C by use of a multiplex allele-specific assay. J Clin Microbiol 51:3666-74
Wang, Dongning; Hicks, Charles B; Goswami, Neela D et al. (2011) Evolution of drug-resistant viral populations during interruption of antiretroviral therapy. J Virol 85:6403-15
Liu, Jia; Miller, Michael D; Danovich, Robert M et al. (2011) Analysis of low-frequency mutations associated with drug resistance to raltegravir before antiretroviral treatment. Antimicrob Agents Chemother 55:1114-9
Lu, Xiaozhi; Hora, Bhavna; Cai, Fangping et al. (2010) Generation of random mutant libraries with multiple primers in a single reaction. J Virol Methods 167:146-51
Ramadhani, Habib O; Thielman, Nathan M; Landman, Keren Z et al. (2007) Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania. Clin Infect Dis 45:1492-8
Masse, Sherie; Lu, Xiaozhi; Dekhtyar, Tatyana et al. (2007) In vitro selection and characterization of human immunodeficiency virus type 2 with decreased susceptibility to lopinavir. Antimicrob Agents Chemother 51:3075-80
Cai, Fangping; Chen, Haifeng; Hicks, Charles B et al. (2007) Detection of minor drug-resistant populations by parallel allele-specific sequencing. Nat Methods 4:123-5
Gao, Feng; Chen, Yalu; Levy, David N et al. (2004) Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious. J Virol 78:2426-33