Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM067134-03
Application #
6933389
Study Section
Special Emphasis Panel (ZRG1-CDF-4 (02))
Program Officer
Anderson, Richard A
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-06-01
Budget End
2004-12-31
Support Year
3
Fiscal Year
2004
Total Cost
$164,807
Indirect Cost
Name
Wayne State University
Department
Pathology
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Ramakrishnan, Gopalakrishnan; Davaakhuu, Gantulga; Kaplun, Ludmila et al. (2014) Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. J Biol Chem 289:6054-66
Leicht, Deborah T; Balan, Vitaly; Zhu, Jun et al. (2013) MEK-1 activates C-Raf through a Ras-independent mechanism. Biochim Biophys Acta 1833:976-86
Tzivion, Guri; Hay, Nissim (2011) PI3K-AKT-FoxO axis in cancer and aging. Biochim Biophys Acta 1813:1925
Dobson, Melissa; Ramakrishnan, Gopalakrishnan; Ma, Stephanie et al. (2011) Bimodal regulation of FoxO3 by AKT and 14-3-3. Biochim Biophys Acta 1813:1453-64
Balan, Vitaly; Miller, Gregory S; Kaplun, Ludmila et al. (2008) Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem 283:27810-9
Leicht, Deborah T; Balan, Vitaly; Kaplun, Alexander et al. (2007) Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta 1773:1196-212
Tzivion, Guri (2007) Special issue on mitogen-activated protein kinases: New insights into regulation, function and role in human disease. Biochim Biophys Acta 1773:1149
Tzivion, Guri; Gupta, Vinita Singh; Kaplun, Ludmila et al. (2006) 14-3-3 proteins as potential oncogenes. Semin Cancer Biol 16:203-13
Balan, Vitaly; Leicht, Deborah T; Zhu, Jun et al. (2006) Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol Biol Cell 17:1141-53
Zhu, Jun; Balan, Vitaly; Bronisz, Agnieszka et al. (2005) Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell 16:4733-44

Showing the most recent 10 out of 12 publications