Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM067143-21
Application #
6743658
Study Section
Allergy and Immunology Study Section (ALY)
Program Officer
Marino, Pamela
Project Start
1983-02-01
Project End
2006-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
21
Fiscal Year
2004
Total Cost
$341,925
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Riddle, David S; Miller, Peter J; Vincent, Benjamin G et al. (2008) Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. Eur J Immunol 38:1511-21
Tian, Shaomin; Maile, Robert; Collins, Edward J et al. (2007) CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate. J Immunol 179:2952-60
Hess, Paul R; Barnes, Carie; Woolard, Matthew D et al. (2007) Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood 109:3300-7
Maile, Robert; Pop, Shannon M; Tisch, Roland et al. (2006) Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol 36:397-410
Buchanan, Ian B; Maile, Robert; Frelinger, Jeffrey A et al. (2006) The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation. J Trauma 61:1062-8
Maile, Robert; Barnes, Carie M; Nielsen, Alma I et al. (2006) Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury. J Immunol 176:6717-26
Maile, Robert; Siler, Catherine A; Kerry, Samantha E et al. (2005) Peripheral ""CD8 tuning"" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol 174:619-27
Kerry, Samantha E; Maile, Robert; Collins, Edward J et al. (2005) Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production. Immunology 114:44-52
Lindesmith, Lisa; Moe, Christine; Lependu, Jacques et al. (2005) Cellular and humoral immunity following Snow Mountain virus challenge. J Virol 79:2900-9
Rockx, Barry; Baric, Ralph S; de Grijs, Ingrid et al. (2005) Characterization of the homo- and heterotypic immune responses after natural norovirus infection. J Med Virol 77:439-46

Showing the most recent 10 out of 16 publications