Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
9R01GM067308-05A2
Application #
6471576
Study Section
Special Emphasis Panel (ZRG1-GRM (02))
Program Officer
Okita, Richard T
Project Start
2002-08-15
Project End
2006-07-31
Budget Start
2002-08-15
Budget End
2003-07-31
Support Year
5
Fiscal Year
2002
Total Cost
$302,469
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Quinney, Sara K; Malireddy, Srikar R; Vuppalanchi, Raj et al. (2013) Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. Eur J Clin Pharmacol 69:439-48
Quinney, Sara K; Zhang, Xin; Lucksiri, Aroonrut et al. (2010) Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin. Drug Metab Dispos 38:241-8
Ogburn, Evan T; Jones, David R; Masters, Andrea R et al. (2010) Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation. Drug Metab Dispos 38:1218-29
Zhou, Jihao; Qin, Zhaohui; Quinney, Sara K et al. (2009) A new probabilistic rule for drug-dug interaction prediction. J Pharmacokinet Pharmacodyn 36:1-18
Kim, Seongho; Hall, Stephen D; Li, Lang (2009) A novel Gibbs maximum a posteriori (GMAP) approach on Bayesian nonlinear mixed-effects population pharmacokinetics (PK) models. J Biopharm Stat 19:700-20
Zhou, Jihao; Qin, Zhaohui; Sara, Quinney K et al. (2009) Drug-drug interaction prediction assessment. J Biopharm Stat 19:641-57
Yu, Menggang; Kim, Seongho; Wang, Zhiping et al. (2008) A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction. J Biopharm Stat 18:1063-83
Jin, Y; Wang, Y-H; Miao, J et al. (2007) Cytochrome P450 3A5 genotype is associated with verapamil response in healthy subjects. Clin Pharmacol Ther 82:579-85
Li, Lang; Yu, Menggang; Chin, Raymond et al. (2007) Drug-drug interaction prediction: a Bayesian meta-analysis approach. Stat Med 26:3700-21
Wang, Ying-Hong; Jones, David R; Hall, Stephen D (2004) Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos 32:259-66