Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM070639-01S1
Application #
6943819
Study Section
Radiation Therapeutics and Biology Study Section (RTB)
Program Officer
Anderson, Richard A
Project Start
2004-07-01
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$49,735
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Hanakahi, Les (2011) Effect of the inositol polyphosphate InsP(6) on DNA-PK-dependent phosphorylation. Mol Cancer Res 9:1366-76
Cheung, Joyce C Y; Salerno, Brenda; Hanakahi, Les A (2008) Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase. Nucleic Acids Res 36:5713-26
Jayaram, Sumithra; Ketner, Gary; Adachi, Noritaka et al. (2008) Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF. Nucleic Acids Res 36:5773-86
Jayaram, Sumithra; Gilson, Timra; Ehrlich, Elana S et al. (2008) E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection. Virology 382:163-70
Mason, Tracey McGregor; Smeaton, Michael B; Cheung, Joyce C Y et al. (2008) End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion. Bioconjug Chem 19:1064-70
Hanakahi, Les A (2007) 2-Step purification of the Ku DNA repair protein expressed in Escherichia coli. Protein Expr Purif 52:139-45
Smeaton, Michael B; Miller, Paul S; Ketner, Gary et al. (2007) Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining. Nucleic Acids Res 35:e152
Baker, Amy; Rohleder, Kent J; Hanakahi, Les A et al. (2007) Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation. J Virol 81:7034-40