The overall goal of the proposed research is to develop the genetic theory necessary for understanding how patterns of co-transmission of host and microbial genomes affect the co-evolution of symbiotic and pathogenic bacteria with their hosts. Our approach is novel in that it extends theory developed for modeling the inheritance of nuclear gene combinations within single genomes to gene combinations across two genomes, those of host and pathogen. When applied to nuclear and mitochondrial gene combinations, this approach successfully predicted the frequency of functional gene transfer from the mitochondria to the nucleus: inter-genomic transfer of functional genes is ten-fold more likely to occur in inbreeding species than in outcrossing species. The reason for this effect of mating system on gene transfer is that mating systems, where mitochondrial and nuclear genes are inherited together, allow natural selection to act more effectively on gene combinations than mating systems where the genes are inherited independently. Although mitochondria are wholly vertically transmitted like some endosymbionts, similar effects are expected to be manifest in systems with only partial vertical transmission and we will develop this more general theory. Two-locus descent theory quantifies the coinheritance of gene combinations in the same or different genomes, determining the degree to which the evolutionary trajectories of genes in each species are conjoined. This determines whether a host-pathogen association will develop toward enhanced virulence or toward benign symbiosis. Project Narrative: Change in the dispersal rates fundamentally change the genetic coevolution both hosts and their pathogens and contribute to the emergence of new diseases. Although a direct link between dispersal of infected hosts and disease epidemiology within a single host generation is well known, the genetic consequences of disease transmission from one generation of hosts to the next is much more poorly understood. This proposal will develop genetic theory for addressing how the co-inheritance of host genes and host pathogens affects the evolution of disease virulence.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM084238-03
Application #
7901491
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Eckstrand, Irene A
Project Start
2008-09-15
Project End
2012-03-31
Budget Start
2010-08-01
Budget End
2012-03-31
Support Year
3
Fiscal Year
2010
Total Cost
$213,444
Indirect Cost
Name
Indiana University Bloomington
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Drury, Douglas W; Dapper, Amy L; Siniard, Dylan J et al. (2017) CRISPR/Cas9 gene drives in genetically variable and nonrandomly mating wild populations. Sci Adv 3:e1601910
Dapper, Amy L; Wade, Michael J (2016) The evolution of sperm competition genes: The effect of mating system on levels of genetic variation within and between species. Evolution 70:502-11
Wolf, Jason B; Wade, Michael J (2016) Evolutionary genetics of maternal effects. Evolution 70:827-39
Ellen, Esther D; Peeters, Katrijn; Verhoeven, Merel et al. (2016) Direct and indirect genetic effects in life-history traits of flour beetles (Tribolium castaneum). Evolution 70:207-17
Wade, Michael J; Drown, Devin M (2016) Nuclear-mitochondrial epistasis: a gene's eye view of genomic conflict. Ecol Evol 6:6460-6472
Dapper, Amy L; Lively, Curtis M (2014) Interlocus sexually antagonistic coevolution can create indirect selection for increased recombination. Evolution 68:1216-24
Drown, Devin M; Wade, Michael J (2014) Runaway coevolution: adaptation to heritable and nonheritable environments. Evolution 68:3039-46
Wade, Michael J (2014) Paradox of mother's curse and the maternally provisioned offspring microbiome. Cold Spring Harb Perspect Biol 6:a017541
Drown, Devin M; Zee, Peter C; Brandvain, Yaniv et al. (2013) Evolution of transmission mode in obligate symbionts. Evol Ecol Res 15:43-59
Drown, Devin M; Dybdahl, Mark F; Gomulkiewicz, Richard (2013) Consumer-resource interactions and the evolution of migration. Evolution 67:3290-304

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