This proposal describes the continued maintenance and development of the Gene Wiki, the goal of which is to create a continuously-updated, community-reviewed, and collaboratively-written review article for every human gene. The Gene Wiki was created directly within Wikipedia as an informal collection of 10,646 gene-specific articles. In the first funding period, the infrastructure to keep Gene Wiki """"""""infoboxes"""""""" in sync wit the source databases in the genomics community was developed. Next, methods to assess and quantify the trustworthiness of each word of a Gene Wiki article were developed and implemented in a system called WikiTrust. And finally, simple text-mining applied to Gene Wiki was able to identify thousands of novel gene annotations. During the next project period, the Gene Wiki is poised to make further strides. First, the scope of the Gene Wiki will be expanded to also include review articles on diseases and drugs. Thousands of articles will either be created or maintained through this initiative with a particular emphasis on rare diseases. Second, a dedicated outreach component will ensure that the community of editors is poised to grow. This outreach effort will engage both faculty members who are experts on specific genes of interest, as well as classroom instructors at all levels who want to design curriculum based on the Gene Wiki for a class project. Third, a """"""""Centralized Model Organism Database"""""""" will be constructed in the Wikidata environment, which will serve as a clearing house of microbial gene and genome annotation data. And fourth an entirely new crowdsourcing application will be created that taps into crowds of patient-aligned individuals and their desire to advance research. These individuals will be a novel crowd that will be applied to the challenge of systematically annotating the biomedical literature. In summary, the Gene Wiki is a useful tool for biomedical research. Successful completion of this proposal will result in more efficient knowledge management and dissemination through crowdsourcing.

Public Health Relevance

The Gene Wiki is a highly used resource for understanding gene function. The goal of this project is to create a collaboratively-written, community-reviewed, and continuously-updated review article for every human gene, drug, and disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Project (R01)
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Study Section
Biodata Management and Analysis Study Section (BDMA)
Program Officer
Lyster, Peter
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Scripps Research Institute
La Jolla
United States
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Pecci, Alessandro; Ma, Xuefei; Savoia, Anna et al. (2018) MYH9: Structure, functions and role of non-muscle myosin IIA in human disease. Gene 664:152-167
Janes, Jeff; Young, Megan E; Chen, Emily et al. (2018) The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis. Proc Natl Acad Sci U S A 115:10750-10755
Daniel, Dianne C; Johnson, Edward M (2018) PURA, the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functions. Gene 643:133-143
Schmidt, Laura S; Linehan, W Marston (2018) FLCN: The causative gene for Birt-Hogg-Dubé syndrome. Gene 640:28-42
Wang, Jie; Lee, Jessica; Liem, David et al. (2017) HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum. Gene 618:14-23
Froimchuk, Eugene; Jang, Younghoon; Ge, Kai (2017) Histone H3 lysine 4 methyltransferase KMT2D. Gene 627:337-342
Lin, Dasheng; Alberton, Paolo; Caceres, Manuel Delgado et al. (2017) Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing. Cell Death Dis 8:e3116
Chen, Kong; Kolls, Jay K (2017) Interluekin-17A (IL17A). Gene 614:8-14
Ghaleb, Amr M; Yang, Vincent W (2017) Krüppel-like factor 4 (KLF4): What we currently know. Gene 611:27-37
Griffith, Malachi; Spies, Nicholas C; Krysiak, Kilannin et al. (2017) CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. Nat Genet 49:170-174

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