Much of the theory of host-pathogen interactions is aimed at understanding the circumstances that lead to cycles in pathogen incidence or host density. This theory usually assumes that host and pathogen have strong effects on each other, which should in principle lead to strong natural selection on both host and pathogen. Natural selection on host resistance and pathogen virulence may therefore play a role in host-pathogen cycles, but this possibility is almost never allowed for in standard theory. This conceptual issue is of great applied importance in the case of out breaking forest insects, such as the gypsy moth that the Pi's propose to study. Like many forest insects, the gypsy moth undergoes huge swings in density, and the economic damage caused by peak populations is reduced by epizootics (= epidemics in animal species) of fatal baculoviruses. Because insect larvae are not very mobile, and because the biology of baculovirus transmission is relatively simple, it is possible to accurately quantify baculovirus transmission using small-scale experiments in the field. The PI and colleagues therefore propose to use the gypsy moth-baculovirus interaction as a model experimental system to ask, does the evolution of host resistance or pathogen virulence play a significant role in insect outbreaks? To answer this question, they will first carry out small scale experiments that disentangle components of host and pathogen fitness. These experiments will focus on estimating the parameters of a range of mathematical models, each making different assumptions about the effects of natural selection on resistance and virulence. Based on these parameter values, the models will be used to generate predictions, and the model predictions will be tested through comparison to data on outbreaks in nature. If models that include host or pathogen evolution do a better job of explaining data on outbreaks, the Pi's will conclude that host and pathogen evolution play a role in insect outbreaks in nature.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM096655-01
Application #
8066157
Study Section
Special Emphasis Panel (ZRG1-BDA-A (80))
Program Officer
Eckstrand, Irene A
Project Start
2010-09-01
Project End
2014-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
1
Fiscal Year
2010
Total Cost
$304,499
Indirect Cost
Name
University of Chicago
Department
Biology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Páez, David J; Dukic, Vanja; Dushoff, Jonathan et al. (2017) Eco-Evolutionary Theory and Insect Outbreaks. Am Nat 189:616-629
Eakin, Libby; Wang, Mei; Dwyer, Greg (2015) The effects of the avoidance of infectious hosts on infection risk in an insect-pathogen interaction. Am Nat 185:100-12
Páez, D J; Fleming-Davies, A E; Dwyer, G (2015) Effects of pathogen exposure on life-history variation in the gypsy moth (Lymantria dispar). J Evol Biol 28:1828-39
Hughes, Josie S; Cobbold, Christina A; Haynes, Kyle et al. (2015) Effects of forest spatial structure on insect outbreaks: insights from a host-parasitoid model. Am Nat 185:E130-52
Fleming-Davies, Arietta E; Dwyer, Greg (2015) Phenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence. Am Nat 186:797-806
Kennedy, David A; Dukic, Vanja; Dwyer, Greg (2014) Pathogen growth in insect hosts: inferring the importance of different mechanisms using stochastic models and response-time data. Am Nat 184:407-23
Elderd, Bret D; Dwyer, Greg; Dukic, Vanja (2013) Population-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics. Epidemics 5:146-56
Elderd, Bret D; Rehill, Brian J; Haynes, Kyle J et al. (2013) Induced plant defenses, host-pathogen interactions, and forest insect outbreaks. Proc Natl Acad Sci U S A 110:14978-83
Fuller, Emma; Elderd, Bret D; Dwyer, Greg (2012) Pathogen persistence in the environment and insect-baculovirus interactions: disease-density thresholds, epidemic burnout, and insect outbreaks. Am Nat 179:E70-96
Barrett, Luke G; Bell, Thomas; Dwyer, Greg et al. (2011) Cheating, trade-offs and the evolution of aggressiveness in a natural pathogen population. Ecol Lett 14:1149-57