Abstract

Most evolution is the result of modifications of biological function by natural selection. However, truly novel evolutionary innovations are also possible. One example is the recruitment of genes from ancestrally non-genic sequence, which has been described in several species using comparative genomics approaches. Here we focus on the early stages of de novo gene evolution by studying variation and function of such genes segregating in Drosophila melanogaster and fixed since the split with D. simulans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM110258-02
Application #
9023562
Study Section
Genetic Variation and Evolution Study Section (GVE)
Program Officer
Janes, Daniel E
Project Start
2015-03-01
Project End
2019-02-28
Budget Start
2016-03-01
Budget End
2017-02-28
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Adrion, Jeffrey R; Begun, David J; Hahn, Matthew W (2018) Patterns of transposable element variation and clinality in Drosophila. Mol Ecol :
Zhao, Li; Begun, David J (2017) Genomics of parallel adaptation at two timescales in Drosophila. PLoS Genet 13:e1007016
Svetec, Nicolas; Cridland, Julie M; Zhao, Li et al. (2016) The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. PLoS Genet 12:e1005869
Sedghifar, Alisa; Saelao, Perot; Begun, David J (2016) Genomic Patterns of Geographic Differentiation in Drosophila simulans. Genetics 202:1229-40
Schrider, Daniel R; Hahn, Matthew W; Begun, David J (2016) Parallel Evolution of Copy-Number Variation across Continents in Drosophila melanogaster. Mol Biol Evol 33:1308-16
Svetec, Nicolas; Zhao, Li; Saelao, Perot et al. (2015) Evidence that natural selection maintains genetic variation for sleep in Drosophila melanogaster. BMC Evol Biol 15:41
Zhao, Li; Wit, Janneke; Svetec, Nicolas et al. (2015) Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans. PLoS Genet 11:e1005184