Environmental stress has direct but complex effects on human health. Phenotypic plasticity in response to environmental stress may result in both adaptations necessary for survival as well as pathologies detrimental to well-being. The model organism Caenorhabditis elegans enters into a stress-resistant 'dauer' stage in response to adverse environmental conditions. The dauer is a classic example of developmental and behavioral plasticity. We previously showed that the dauers undergo extensive and reversible neuronal remodeling in a set of IL2 sensory neurons and that this remodeling is dependent on the furin homolog, KPC-1. During this grant period we will: 1) Extend our investigations into the role of KPC-1 in remodeling by identifying substrates. Furthermore, we will investigate the role of KPC-1 in additional stages of phenotype plasticity in C. elegans. 2) Characterize mutants isolated from a mutagenesis screen that are defective in IL2 remodeling 3) Analyze the ultra-structural properties of the IL2 to uncover the requirements necessary for their inherent plasticity.
Environmental stress can result in structural changes to the nervous system resulting in chronic pathologies. This grant will use the model organism C. elegans to elucidate the genetics behind neuroplasticity in response to stress.
|Han, Ziduan; Thapa, Sita; Reuter-Carlson, Ursula et al. (2018) Immobility in the sedentary plant-parasitic nematode H. glycines is associated with remodeling of neuromuscular tissue. PLoS Pathog 14:e1007198|
|Androwski, Rebecca J; Flatt, Kristen M; Schroeder, Nathan E (2017) Phenotypic plasticity and remodeling in the stress-induced Caenorhabditis elegans dauer. Wiley Interdiscip Rev Dev Biol 6:|
|Han, Ziduan; Boas, Stephanie; Schroeder, Nathan E (2017) Serotonin Regulates the Feeding and Reproductive Behaviors of Pratylenchus penetrans. Phytopathology 107:872-877|
|Molohon, Katie J; Blair, Patricia M; Park, Seongjin et al. (2016) Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane. ACS Infect Dis 2:207-220|
|Han, Ziduan; Boas, Stephanie; Schroeder, Nathan E (2015) Unexpected Variation in Neuroanatomy among Diverse Nematode Species. Front Neuroanat 9:162|