. New strategies for constructing chiral organic molecules can have a significant impact on the production of important medicinally-active compounds and organic materials. The proposed research will develop an unprecedented catalytic conjunctive coupling reaction that results in the combination of three readily available simple organic molecules and establishes a product with a two new C- C bonds and a boron-containing stereogenic center. The reactivity manifold described is the first of its kind and it promises to result in the introduction of an array of new reactions to accomplish the stereoselective synthesis of important chiral compounds.
. Enantiomerically-enriched chiral compounds are important materials in the pharmaceutical industry and have applications in the study of biological processes. The proposed research aims to introduce new processes for the inexpensive, efficient, and selective production of such chiral compounds under the influence of small amounts of specially designed catalysts. In this regards, it can be anticipated that the proposed research will have a significant impact on human healthcare.
| Edelstein, Emma K; Namirembe, Sheila; Morken, James P (2017) Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl)borates: A General Synthesis of Chiral Allylboron Reagents. J Am Chem Soc : |
| Lovinger, Gabriel J; Aparece, Mark D; Morken, James P (2017) Pd-Catalyzed Conjunctive Cross-Coupling between Grignard-Derived Boron ""Ate"" Complexes and C(sp2) Halides or Triflates: NaOTf as a Grignard Activator and Halide Scavenger. J Am Chem Soc 139:3153-3160 |
| Chierchia, Matteo; Law, Chunyin; Morken, James P (2017) Nickel-Catalyzed Enantioselective Conjunctive Cross-Coupling of 9-BBN Borates. Angew Chem Int Ed Engl 56:11870-11874 |
