Most, if not all, fluorinating reagents (electrophilic or nucleophilic) are actually made from hydrogen fluoride (HF). However, the gaseous and corrosive nature of HF excludes it from working laboratories where special equipment and training are not available. The complexes of HF with organic bases like pyridine-HF complex (Olah's reagent) and triethylamine-HF complex have been explored extensively as nucleophilic sources of fluorine, but use of these organic bases reduce the acidity of the system and may interfere with many metal catalysts. So far there is no HF-based nucleophilic fluorination reagent that works well in acid or transition metal catalyzed reactions. Our primary goal is to develop a new generation of HF-based nucleophilic fluorination reagents that is compatible with acids and metal catalysts based on a rational design. The same strategy can also be used for new HX (X = Cl, Br, I)-based halogenation reagents. Hydrogen bonding, rather than an ionic interaction, has been identified as the major interaction between HF and an organic base in complexes such as pyridine-HF (Olah's reagent). To reduce the volatility of an HF complex (make it a liquid or solid at room temperature), we have to use a relatively good hydrogen bonding acceptor (HBA) to complex with HF. Our hypothesis is: a strong (good) hydrogen bonding acceptor is not necessarily a strong base (Brnsted or Lewis base). In this way, a compound that serves as good hydrogen bonding acceptor (better than pyridine or triethylamine), but is less basic, is expected to form a less volatile complex. And due to the low basicity of this HBA, the resulting HBA-HF complex will be compatible with acid catalysts or mediators. In this manner, we may achieve unprecedented reactivity and selectivity in HF-participating reactions. The first part of our research is the preparation of HBA-HX complexes. We are seeking `anomaly' HBAs, that is, good hydrogen bond acceptors but weak Brnsted bases. The quantitative descriptor of hydrogen bond basicity and Brnsted basicity shown in Figure 1 (based on Laurence and co-workers' database of hydrogen-bond basicity) is our primary guideline for the selection of suitable hydrogen bonding acceptors. The nucleophilic fluorination reagents proposed and the methodologies for their use will enable diverse-oriented, stereo- and regio-selective synthesis of fluoroamines, fluorohydrins, fluoroaminoacids, fluorinated aliphatic, alkenes, cyclic and heterocyclic compounds, through new synthetic protocols such as tandem HF-addition-metathesis, HF trapping in cationic cascade reactions, strain-release nucleophilic fluorinations, in-situ electrophilic fluorine formation, Markovnikov and anti-Markovnikov hydrofluorinations. A similar strategy will be used to develop designer-HX based (X = Cl, Br, I) halogenation reagents. One of our reagents (DMPU-HF) is already commercially available, and we will commercialize other newly developed reagents to make our methods available to medicinal chemists worldwide.

Public Health Relevance

Because of fluorine's unique properties?small size and metabolically resistant C-F bond--the selective substitution of hydrogen by fluorine constitutes a key strategy in drug discovery. In most commercial drugs and agrochemicals, fluorine is attached to aromatic moieties. Indeed, the chemical space of non-aromatic fluorine in medicinal chemistry is very narrow because fluorine is not an easy atom to introduce in aliphatic or cyclic systems. Fluoroaliphatic or fluoroheterocycles are currently prepared on a case-by-case basis using boutique-type reactions. Our primary goal is to develop of a new generation of HF-based nucleophilic fluorination reagents that are compatible with acids and metal catalysts based on rational design so as to open the door for reactivities and selectivities hitherto unknown. The nucleophilic fluorination reagents proposed and the methodologies for their use will enable diverse-oriented, stereo- and regio-selective synthesis of fluoroamines, fluorohydrins, fluoroaminoacids, fluorinated aliphatic, alkenes, cyclic and heterocyclic compounds, through new synthetic protocols such as tandem HF-addition-metathesis, HF trapping in cationic cascade reactions, strain-release nucleophilic fluorinations, in-situ electrophilic fluorine formation, Markovnikov and anti-Markovnikov hydrofluorinations. A similar strategy will be used to develop designer-HX based (X = Cl, Br, I) halogenation reagents.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM121660-01
Application #
9219315
Study Section
Synthetic and Biological Chemistry A Study Section (SBCA)
Program Officer
Lees, Robert G
Project Start
2016-12-06
Project End
2021-11-30
Budget Start
2016-12-06
Budget End
2017-11-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Louisville
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Liang, Shengzong; Hammond, Gerald B; Xu, Bo (2018) Metal-free Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System. Green Chem 20:680-684
Zeng, Xiaojun; Liu, Shiwen; Hammond, Gerald B et al. (2018) Hydrogen-Bonding-Assisted Brønsted Acid and Gold Catalysis: Access to Both (E)- and (Z)-1,2-Haloalkenes via Hydrochlorination of Haloalkynes. ACS Catal 8:904-909
Ebule, Rene; Hammond, Gerald B; Xu, Bo (2018) Metal-free Chlorothiolation of Alkenes using HCl and Sulfoxides. European J Org Chem 2018:4705-4708
Zeng, Xiaojun; Li, Junling; Ng, Chin K et al. (2018) (Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster. Angew Chem Int Ed Engl 57:2924-2928
Sedgwick, Daniel M; López, Inés; Román, Raquel et al. (2018) Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins. Org Lett 20:2338-2341
Zeng, Xiaojun; Lu, Zhichao; Liu, Shiwen et al. (2017) Metal-free, Regio-, and Stereo-Controlled Hydrochlorination and Hydrobromination of Ynones and Ynamides. J Org Chem 82:13179-13187
Zeng, Xiaojun; Liu, Shiwen; Hammond, Gerald B et al. (2017) Divergent Regio- and Stereoselective Gold-catalyzed Synthesis of ?-Fluorosulfones and ?-Fluorovinylsulfones from Alkynylsulfones. Chemistry 23:11977-11981
Liang, Shengzong; Barrios, Francis J; Okoromoba, Otome E et al. (2017) Bromofluorination of Unsaturated Compounds using DMPU/HF as a Fluorinating Reagent. J Fluor Chem 203:136-139
Zeng, Xiaojun; Lu, Zhichao; Liu, Shiwen et al. (2017) Gold-catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3-Dicarbonyl Compounds. Adv Synth Catal 359:4062-4066
Liang, Shengzong; Ebule, Rene; Hammond, Gerald B et al. (2017) A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis. Org Lett 19:4524-4527

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