Abstract

This research will examine the effects of phototherapy as used in neonatal jaundice and shorter wave length light as used in photochemotherapy in drug metabolizing enzymes of the liver and skin of jaundiced and normal rats. We intend to examine the effects of displacement of bilirubin from plasma protein binding sites by sulfadimethoxine in pregnancy of bile duct ligated rats. The interaction of phototherapy, hyperbilirubinemia and selected photodynamic agents including riboflavin and tetracycline will be investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD003867-16
Application #
3310223
Study Section
Toxicology Study Section (TOX)
Project Start
1978-12-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1987-11-30
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Type
Schools of Veterinary Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Gu, Y; Davis, D R; Lin, Y C (1989) Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats. Arch Androl 22:131-6
Davis, D R; Bail, S P (1988) Tin-protoporphyrin suppression of hyperbilirubinemia in the jaundiced Gunn rat. Dev Pharmacol Ther 11:281-7
Davis, D R; Yeary, R A; Bail, S P (1987) Transfer of the heritable nonhemolytic jaundice trait from the Gunn rat to the Sprague-Dawley rat. Lab Anim Sci 37:172-5
Davis, D R; Yeary, R A (1987) Activated charcoal as an adjunct to phototherapy for neonatal jaundice. Dev Pharmacol Ther 10:12-20