Abstract

The long term objective of this research program is to determine how the brain regulates feminine sexual behavior in laboratory animals. Since this behavior is influenced by ovarian hormones acting in specific brain regions, experimentation focuses on the mechanism of hormone action at these specific brain sites. This research program utilizes chemical stimulation of the brain to determine the potential influence of specific brain receptors, assay procedures to measure endogenous changes in putative neurotransmitter systems and analysis of brain extracts to determine endogenous brain factors that control feminine sexual responses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD006760-14
Application #
3310575
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1978-06-01
Project End
1986-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Michigan State University
Department
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

Wagner, C K; Popper, P; Ulibarri, C et al. (1994) Calcitonin gene-related peptide-like immunoreactivity in spinal motoneurons of the male mouse is affected by castration and genotype. Brain Res 647:37-43
Wagner, C K; Clemens, L G (1991) Projections of the paraventricular nucleus of the hypothalamus to the sexually dimorphic lumbosacral region of the spinal cord. Brain Res 539:254-62
Wagner, C K; Clemens, L G (1989) Perinatal modification of a sexually dimorphic motor nucleus in the spinal cord of the B6D2F1 house mouse. Physiol Behav 45:831-5
Wagner, C K; Clemens, L G (1989) Anatomical organization of the sexually dimorphic perineal neuromuscular system in the house mouse. Brain Res 499:93-100
Wee, B E; Clemens, L G (1989) Environmental influences on masculine sexual behavior in mice. Physiol Behav 46:867-72
Clemens, L G; Barr, P; Dohanich, G P (1989) Cholinergic regulation of female sexual behavior in rats demonstrated by manipulation of endogenous acetylcholine. Physiol Behav 45:437-42
Richmond, G; Clemens, L (1988) Ventromedial hypothalamic lesions and cholinergic control of female sexual behavior. Physiol Behav 42:179-82
Clemens, L G; Wee, B E; Weaver, D R et al. (1988) Retention of masculine sexual behavior following castration in male B6D2F1 mice. Physiol Behav 42:69-76
Wee, B E; Weaver, D R; Clemens, L G (1988) Hormonal restoration of masculine sexual behavior in long-term castrated B6D2F1 mice. Physiol Behav 42:77-82
Witcher, J A; Clemens, L G (1987) A prenatal source for defeminization of female rats is the maternal ovary. Horm Behav 21:36-43

Showing the most recent 10 out of 14 publications